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Literature summary for 5.6.2.2 extracted from
- Kinetic pathways of topology simplification by type-II topoisomerases in knotted supercoiled DNA (2019), Nucleic Acids Res., 47, 69-84 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme activity is significantly enhanced in DNA molecules that maintain a supercoiled state with constant torsional tension | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + knotted supercoiled DNA | - |
Homo sapiens | ADP + phosphate + unknotted relaxed DNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| type-II topoisomerase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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