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Literature summary for 5.6.2.2 extracted from
- Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast (2019), J. Biol. Chem., 294, 3772-3782 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S1363A/S1364A | the non-phosphorylatable alanine double mutant maintains decatenation activity but has lost much of its ability to hydrolyze ATP as compared to the wild type enzyme | Schizosaccharomyces pombe |
| S1363E/S1364E | phosphomimetic double mutant | Schizosaccharomyces pombe |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ICRF-193 | i.e., meso-4,4-(2,3-butanediyl)-bis (2,6-piperazinedione) | Schizosaccharomyces pombe |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | casein kinase II phosphorylates the C-terminal residues Ser-1363 and Ser-1364 | Schizosaccharomyces pombe |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + kinetoplast DNA | - |
Schizosaccharomyces pombe | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase II | - |
Schizosaccharomyces pombe |
| Top2 | - |
Schizosaccharomyces pombe |
| topo II | - |
Schizosaccharomyces pombe |
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Release 2023.1 (January 2023)
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