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Literature summary for 5.6.2.2 extracted from

  • Janezic, M.; Pogorelcnik, B.; Brvar, M.; Solmajer, T.; Perdih, A.
    3-substituted-1H-indazoles as catalytic inhibitors of the human DNA topoisomerase IIalpha (2017), ChemistrySelect, 2, 480-488 .
No PubMed abstract available
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
1-[(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)(ethyl)amino]-1-oxopropan-2-yl 1H-indazole-3-carboxylate
-
 Homo sapiens
1-[4-[(methanesulfonyl)amino]phenyl]-1-oxopropan-2-yl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-oxo-2-(3-sulfamoylanilino)ethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[(1,1-dioxo-1l6-thiolan-3-yl)(ethyl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[(1,1-dioxo-1l6-thiolan-3-yl)(methyl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[(1,1-dioxo-1l6-thiolan-3-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)(2-methylpropyl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[(3-carbamoylthiophen-2-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[(butan-2-yl)(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[4-(methanesulfonyl)piperazin-1-yl]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
2-[benzyl(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
-
 Homo sapiens
4-(benzylsulfanyl)-6-[[(2-fluorophenyl)methyl]sulfanyl]-1,3,5-triazin-2(1H)-one
-
 Homo sapiens
4-(benzylsulfanyl)-6-[[(3-chlorophenyl)methyl]sulfanyl]-1,3,5-triazin-2(1H)-one
-
 Homo sapiens
amsacrine
-
 Homo sapiens
daunorubicin
-
 Homo sapiens
dexrazoxane i.e, ICRF-187 Homo sapiens
doxorubicin
-
 Homo sapiens
etoposide
-
 Homo sapiens
Merbarone
-
 Homo sapiens
Mitoxantrone
-
 Homo sapiens
N-([3-[(methanesulfonyl)amino]phenyl]methyl)-1H-indazole-3-carboxamide
-
 Homo sapiens
N-([4-[(methylsulfamoyl)methyl]phenyl]methyl)-1H-indazole-3-carboxamide
-
 Homo sapiens
N-[1-(1H-indazole-3-carbonyl)piperidin-4-yl]methanesulfonamide
-
 Homo sapiens
N-[1-(1H-indazole-3-carbonyl)piperidin-4-yl]methanesulfonohydrazide
-
 Homo sapiens
N-[1-(1H-indazole-3-carbonyl)piperidin-4-yl]propane-1-sulfonamide
-
 Homo sapiens
N-[3-[(methanesulfonyl)amino]propyl]-1H-indazole-3-carboxamide
-
 Homo sapiens
N-[4-[(methanesulfonyl)amino]-3-methylphenyl]-1H-indazole-3-carboxamide
-
 Homo sapiens
N-[4-[(methanesulfonyl)amino]phenyl]-1H-indazole-3-carboxamide
-
 Homo sapiens
Teniposide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
DNA topoisomerase IIalpha
-
 Homo sapiens
tIIalpha
-
 Homo sapiens
Topo IIalpha
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0139
-
 pH and temperature not specified in the publication Homo sapiens N-[1-(1H-indazole-3-carbonyl)piperidin-4-yl]methanesulfonohydrazide
0.0236
-
 pH and temperature not specified in the publication Homo sapiens 2-[benzyl(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
0.0242
-
 pH and temperature not specified in the publication Homo sapiens 2-[(1,1-dioxo-1l6-thiolan-3-yl)(ethyl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
0.0251
-
 pH and temperature not specified in the publication Homo sapiens N-[1-(1H-indazole-3-carbonyl)piperidin-4-yl]methanesulfonamide
0.0256
-
 pH and temperature not specified in the publication Homo sapiens 1-[4-[(methanesulfonyl)amino]phenyl]-1-oxopropan-2-yl 1H-indazole-3-carboxylate
0.0268
-
 pH and temperature not specified in the publication Homo sapiens 2-oxo-2-(3-sulfamoylanilino)ethyl 1H-indazole-3-carboxylate
0.0289
-
 pH and temperature not specified in the publication Homo sapiens 2-[(1,1-dioxo-1l6-thiolan-3-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
0.0458
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(methanesulfonyl)amino]phenyl]-1H-indazole-3-carboxamide
0.06454
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-(methanesulfonyl)piperazin-1-yl]-2-oxoethyl 1H-indazole-3-carboxylate
0.1963
-
 pH and temperature not specified in the publication Homo sapiens 2-[(1,1-dioxo-1l6-thiolan-3-yl)(methyl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
0.2146
-
 pH and temperature not specified in the publication Homo sapiens 2-[(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)(2-methylpropyl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
0.3819
-
 pH and temperature not specified in the publication Homo sapiens N-[3-[(methanesulfonyl)amino]propyl]-1H-indazole-3-carboxamide
0.4767
-
 pH and temperature not specified in the publication Homo sapiens 1-[(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)(ethyl)amino]-1-oxopropan-2-yl 1H-indazole-3-carboxylate
0.5
-
 IC50 above 0.5 mM, pH and temperature not specified in the publication Homo sapiens N-([3-[(methanesulfonyl)amino]phenyl]methyl)-1H-indazole-3-carboxamide
0.5
-
 IC50 above 0.5 mM, pH and temperature not specified in the publication Homo sapiens N-([4-[(methylsulfamoyl)methyl]phenyl]methyl)-1H-indazole-3-carboxamide
0.5
-
 IC50 above 0.5 mM, pH and temperature not specified in the publication Homo sapiens N-[1-(1H-indazole-3-carbonyl)piperidin-4-yl]propane-1-sulfonamide
0.5
-
 IC50 above 0.5 mM, pH and temperature not specified in the publication Homo sapiens N-[4-[(methanesulfonyl)amino]-3-methylphenyl]-1H-indazole-3-carboxamide
1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 2-[(3-carbamoylthiophen-2-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate
1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 2-[(butan-2-yl)(1,1-dioxo-2,3-dihydro-1H-1l6-thiophen-3-yl)amino]-2-oxoethyl 1H-indazole-3-carboxylate