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Literature summary for 5.6.2.2 extracted from
- Two-mechanism model for the interaction of etoposide quinone with topoisomerase IIalpha (2016), Chem. Res. Toxicol., 29, 1541-1548 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Saccharomyces cerevisiae JELDELTAtop1 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| etoposide | - |
Homo sapiens |  |
| etoposide quinone | etoposide quinone inhibits ATP hydrolysis by topoisomerase IIalpha | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + negatively supercoiled pBR322 DNA | - |
Homo sapiens | ADP + phosphate + relaxed pBR322 DNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| topoIIalpha | - |
Homo sapiens |
| topoisomerase IIalpha | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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