Literature summary for 5.6.2.2 extracted from

Mladenovic, M.; Stankovic, N.; Matic, S.; Stanic, S.; Mihailovic, M.; Mihailovic, V.; Katanic, J.; Boroja, T.; Vukovic, N.
Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of topoisomerase IIalpha A story behind the molecular modeling approach (2015), Biochem. Pharmacol., 98, 243-266 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3E)-3-[1-[(2-aminoethyl)amino]ethylidene]-2H-1-benzopyran-2,4(3H)-dione	-	Rattus norvegicus
(3E)-3-[1-[(2-hydroxyethyl)amino]ethylidene]-2H-1-benzopyran-2,4(3H)-dione	-	Rattus norvegicus
(3E,3'E)-3,3'-(1,1'-(ethane-1,2-diylbis(azanediyl))bis(ethan-1-yl-1-ylidene))dichroman-2,4-dione	-	Rattus norvegicus
(3E,3'E)-3,3'-(1,1'-(propane-1,3-diylbis(azanediyl))bis(ethan-1-yl-ylidene))dichroman-2,4-dione	-	Rattus norvegicus
(E)-3-(1-(2-(methylamino)ethylamino)ethylidene)chroman-2,4-dione	-	Rattus norvegicus
(E)-3-(1-(2-mercaptoethylamino)ethylidene)chroman-2,4-dione	-	Rattus norvegicus
4-hydroxy-3-[(1E)-1-([[(1E)-1-(4-hydroxy-2-oxo- 2H-chromen-3yl)ethylidene]sulfamoyl]imino)ethyl]-2H-chromen-2-one	-	Rattus norvegicus
N-[(1E)-1-(4-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene]aminosulfonamide	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.31423	-	ATP	pH and temperature not specified in the publication	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P41516	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + DNA	-	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
topIIalpha	-	Rattus norvegicus
topoisomerase IIalpha	-	Rattus norvegicus

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Release 2023.1 (January 2023)