Literature summary for 5.6.2.2 extracted from

Jacobsen, R.G.; Mazloumi Gavgani, F.; Mellgren, G.; Lewis, A.E.
DNA Topoisomerase IIalpha contributes to the early steps of adipogenesis in 3T3-L1 cells (2016), Cell. Signal., 28, 1593-1603 .

Search for more literature for 5.6.2.2

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q01320	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase IIalpha	-	Mus musculus
Topo IIalpha	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	dependent on	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	inhibition of phosphoinositide 3-kinase with LY294002 and of mTOR with rapamycin consistently reduces the expression of the enzyme	down
Mus musculus	enzyme expression in 3T3-L1 cells is induced within 16 h after the initiation of the differentiation programme, peaks at 24 h and rapidly declines thereafter	up

General Information

General Information	Comment	Organism
physiological function	DNA topoisomerase IIalpha plays an important role in adipogenesis during mitotic clonal expansion in a phosphoinositide 3-kinase/mTOR-dependent manner	Mus musculus

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Release 2023.1 (January 2023)