Literature summary for 5.6.2.2 extracted from

Vann, K.R.; Erguen, Y.; Zencir, S.; Oncuoglu, S.; Osheroff, N.; Topcu, Z.
Inhibition of human DNA topoisomerase IIalpha by two novel ellipticine derivatives (2016), Bioorg. Med. Chem. Lett., 26, 1809-1812 .

Search for more literature for 5.6.2.2

Inhibitors

Inhibitors	Comment	Organism	Structure
2-methyl-N-methyl-5-demethyl ellipticinium iodide	the compound inhibits DNA cleavage without altering the ability of topoisomerase IIalpha to bind its DNA substrate	Homo sapiens
ellipticine	i.e. 5,11-dimethyl-6H-pyrido[4,3-b]carbazole	Homo sapiens
N-methyl-5-demethyl ellipticine	the compound inhibits DNA cleavage without altering the ability of topoisomerase IIalpha to bind its DNA substrate	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
supercoiled DNA + ATP + H2O	Homo sapiens	-	relaxed DNA + ADP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11388	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA + ATP + H2O	-	Homo sapiens	relaxed DNA + ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase IIalpha	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	dependent on	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)