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Literature summary for 5.6.2.2 extracted from

  • Pogorelcnik, B.; Brvar, M.; Zajc, I.; Filipic, M.; Solmajer, T.; Perdih, A.
    Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIalpha (2014), Bioorg. Med. Chem. Lett., 24, 5762-5768 .
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
6-[(2-phenylethyl)sulfanyl]-9H-purin-2-amine
-
 Homo sapiens
6-[(cyclopentylsulfanyl)methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
-
 Homo sapiens
6-[[(1-cyclopentyl-1H-tetrazol-5-yl)sulfanyl]methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
-
 Homo sapiens
6-[[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)sulfanyl]methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
-
 Homo sapiens
N2-(1,3-benzothiazol-6-yl)-N6-cycloheptyl-5,9-dihydro-4H-purine-2,6-diamine
-
 Homo sapiens
N2-(1,3-benzothiazol-6-yl)-N6-tert-butyl-5,9-dihydro-4H-purine-2,6-diamine
-
 Homo sapiens
N2-(4-fluorophenyl)-6-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-1,3,5-triazine-2,4-diamine
-
 Homo sapiens
N2-(4-fluorophenyl)-6-[[(1-propyl-1H-imidazol-2-yl)sulfanyl]methyl]-1,3,5-triazine-2,4-diamine
-
 Homo sapiens
N2-(4-fluorophenyl)-6-[[(1H-tetrazol-5-yl)sulfanyl]methyl]-1,3,5-triazine-2,4-diamine
-
 Homo sapiens
N6-tert-butyl-8-ethyl-N2-[2-[2-(morpholin-4-yl)ethoxy]quinolin-6-yl]-5,9-dihydro-4H-purine-2,6-diamine
-
 Homo sapiens
[4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methyl 4-methylpiperazine-1-carbodithioate
-
 Homo sapiens
[4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methyl cyclohexyl(methyl)carbamodithioate
-
 Homo sapiens
[4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methyl morpholine-4-carbodithioate
-
 Homo sapiens
[4-amino-6-(4-methoxyanilino)-1,3,5-triazin-2-yl]methyl morpholine-4-carbodithioate
-
 Homo sapiens
[4-amino-6-(4-methoxyanilino)-1,3,5-triazin-2-yl]methyl piperidine-1-carbodithioate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11388
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA topoisomerase IIalpha
-
 Homo sapiens
tIIalpha
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.139
-
 pH and temperature not specified in the publication Homo sapiens [4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methyl morpholine-4-carbodithioate
0.229
-
 pH and temperature not specified in the publication Homo sapiens [4-amino-6-(4-methoxyanilino)-1,3,5-triazin-2-yl]methyl morpholine-4-carbodithioate
0.337
-
 pH and temperature not specified in the publication Homo sapiens N2-(4-fluorophenyl)-6-[[(1H-tetrazol-5-yl)sulfanyl]methyl]-1,3,5-triazine-2,4-diamine
1
-
 pH and temperature not specified in the publication Homo sapiens 6-[(cyclopentylsulfanyl)methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
1
-
 pH and temperature not specified in the publication Homo sapiens [4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methyl 4-methylpiperazine-1-carbodithioate
1
-
 pH and temperature not specified in the publication Homo sapiens [4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methyl cyclohexyl(methyl)carbamodithioate
1
-
 pH and temperature not specified in the publication Homo sapiens [4-amino-6-(4-methoxyanilino)-1,3,5-triazin-2-yl]methyl piperidine-1-carbodithioate
1
-
 pH and temperature not specified in the publication Homo sapiens 6-[[(1-cyclopentyl-1H-tetrazol-5-yl)sulfanyl]methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
1
-
 pH and temperature not specified in the publication Homo sapiens N2-(4-fluorophenyl)-6-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-1,3,5-triazine-2,4-diamine
1
-
 pH and temperature not specified in the publication Homo sapiens 6-[[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)sulfanyl]methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
1
-
 pH and temperature not specified in the publication Homo sapiens N2-(4-fluorophenyl)-6-[[(1-propyl-1H-imidazol-2-yl)sulfanyl]methyl]-1,3,5-triazine-2,4-diamine