Literature summary for 5.6.2.2 extracted from

Tian, Q.T.; Ding, C.Y.; Song, S.S.; Wang, Y.Q.; Zhang, A.; Miao, Z.H.
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis (2018), Biochem. Pharmacol., 154, 255-264 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-[3-[ethyl(methyl)amino]propyl]furo[3,2-c]phenanthridine-5,10,11(4H)-trione	-	Homo sapiens
etoposide	topoisomerase II inhibitor	Homo sapiens
N,N-dimethyl(6-methyl-10,11-dioxo-10,11-dihydrophenanthro[1,2-b]furan-1-yl)methanaminium (2E)-3-carboxyprop-2-enoate	-	Homo sapiens
tanshinone-1	less than 10% inhibition at 0.005 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
BEL-7402 cell	-	Homo sapiens	-
CAL-51 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
HCT-15 cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-
KB cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
MDA-MB-436 cell	-	Homo sapiens	-
MDA-MB-468 cell	-	Homo sapiens	-
MX-1 cell	-	Homo sapiens	-
SMMC-7721 cell	-	Homo sapiens	-
SPC-A4 cell	-	Homo sapiens	-
SW-620 cell	-	Homo sapiens	-
UWB1.289 cell	-	Homo sapiens	-
UWB1.289+BRCA1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase II	-	Homo sapiens
Top2	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.02149	-	at pH 8.0 and 37°C	Homo sapiens	tanshinone-1

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Release 2023.1 (January 2023)