Any feedback?
Literature summary for 5.6.2.2 extracted from
- Substrate-mediated proton relay mechanism for the religation reaction in topoisomerase II (2013), J. Biomol. Struct. Dyn., 32, 1759-1765.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP-dependent breakage, passage and rejoining of double-stranded DNA | metal-dependent general acid-base catalysis, quantum mechanical/molecular mechanical calculations for the topo II religation reaction, substrate-mediated proton transfer pathway, which involves the 3'-OH nucleophile, the reactive phosphate, water, Arg781, and Tyr782, metal A stabilizes the transition states, which is consistent with a two-metal mechanism in topo II, overview | Saccharomyces cerevisiae |
aSynonyms
| Synonyms | Comment | Organism |
|---|---|---|
| topo II | - |
Saccharomyces cerevisiae |
| Topoisomerase II | - |
Saccharomyces cerevisiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
