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Literature summary for 5.6.2.2 extracted from

  • Senarisoy, M.; Canturk, P.; Zencir, S.; Baran, Y.; Topcu, Z.
    Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks (2013), Cell Biochem. Biophys., 66, 199-204.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
2,2'-bis(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) i.e. gossypol, belongs to the class II compounds which interfere with the catalytic function of topoisomerases without generating strand breaks Homo sapiens
etoposide
-
 Homo sapiens
additional information supercoiled pRYG substrate is relaxed with topoisomerase II without a significant effect by DMSO Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information recombinant commercial preparation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information decatenation assay with kinetoplast DNA, DNA strand break analysis using supercoiled plasmid DNA pBR322 or pRYG Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Homo sapiens
type II topoisomerase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens