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Literature summary for 5.6.2.2 extracted from

  • Rodríguez, A.C.; Stock, D.
    Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA (2002), EMBO J., 21, 418-426.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Archaeoglobus fulgidus

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop method, crystal structure of the enzyme in the presence and absence of ATP Archaeoglobus fulgidus

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus O29238
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA positively supercoils DNA, the enzyme requires ATP, which is bound and hydrolysed by a helicase-like domain Archaeoglobus fulgidus positively supercoiled DNA
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?

Synonyms

Synonyms Comment Organism
type I topoisomerase
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Archaeoglobus fulgidus

General Information

General Information Comment Organism
physiological function the enzyme appears to be unique to hyperthermophiles, where its activity is believed to protect the genome from denaturation Archaeoglobus fulgidus