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Literature summary for 5.6.2.2 extracted from

  • Baxter, J.; Sen, N.; Lopez Marti­nez, V.; Monturus De Carandini, M.; Schvartzman, J.; Diffley, J.; Aragon, L.
    Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes (2011), Science, 331, 1328-1332.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Saccharomyces cerevisiae 5634
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Synonyms

Synonyms Comment Organism
Topoisomerase II
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function centromeric plasmids undergo a dramatic change in their topology as the cells pass through mitosis. This change is characterized by positive supercoiling of the DNA and requires mitotic spindles and the condensin factor Smc2. When mitotic positive supercoiling occurs on decatenated DNA, it is rapidly relaxed by topoisomerase II. DNA topoisomerase II completely removes DNA intertwining, or catenation, between sister chromatids before they are segregated during cell division. However, when positive supercoiling takes place in catenated plasmid, topoisomerase II activity is directed toward decatenation of the molecules before relaxation. The topological change on DNA drives topoisomerase II to decatenate molecules during mitosis, potentially driving the full decatenation of the genome, mechanism, overview. Once the sister chromatids are fully decatenated, topoisomerase II rapidly relaxes the positive supercoiling generated, returning the intrachromosomal topology of the sister chromatids to a state comparable to that observed before the transition, except that now, crucially, all catenated links have been removed Saccharomyces cerevisiae