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Literature summary for 5.6.2.2 extracted from

  • Cowell, I.G.; Papageorgiou, N.; Padget, K.; Watters, G.P.; Austin, C.A.
    Histone deacetylase inhibition redistributes topoisomerase IIbeta from heterochromatin to euchromatin (2011), Nucleus, 2, 61-71.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
epirubicin a so called topoisomerase poison, which stabilizes the enzyme-linked double-strand break, that is otherwise transient and rapidly religated Homo sapiens
epirubicin a so called topoisomerase poison, which stabilizes the enzyme-linked double-strand break, that is otherwise transient and rapidly religated Mus musculus
etoposide a so called topoisomerase poison, which stabilizes the enzyme-linked double-strand break, that is otherwise transient and rapidly religated Homo sapiens
etoposide a so called topoisomerase poison, which stabilizes the enzyme-linked double-strand break, that is otherwise transient and rapidly religated Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin topoisomerase IIbeta is heterochromatin-associated Mus musculus 785
-
chromatin topoisomerase IIbeta is heterochromatin-associated Homo sapiens 785
-
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
C127I cell
-
 Mus musculus
-
K-562 cell
-
 Homo sapiens
-
NALM-6 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
dimer
-
 Mus musculus
dimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
topoIIbeta
-
 Mus musculus
topoIIbeta
-
 Homo sapiens
topoisomerase IIbeta
-
 Mus musculus
topoisomerase IIbeta
-
 Homo sapiens

General Information

General Information Comment Organism
additional information histone deacetylase inhibition, e.g., by trichostatin A, redistributes topoisomerase IIbeta from heterochromatin to euchromatin, overview. Treatment with trichostatin A displaces topoIIbeta from the heterochromatin with similar kinetics to the displacement of HP1beta proteins Mus musculus
additional information histone deacetylase inhibition, e.g., by trichostatin A, redistributes topoisomerase IIbeta from heterochromatin to euchromatin, overview. Treatment with trichostatin A displaces topoIIbeta from the heterochromatin with similar kinetics to the displacement of HP1beta proteins Homo sapiens
physiological function topoisomerase II is an essential enzyme that allows the passage of one DNA duplex through a second one. The enzyme introduces an enzyme-bridged DNA double-strand break in one double helix through which a second duplex can be passed Mus musculus
physiological function topoisomerase II is an essential enzyme that allows the passage of one DNA duplex through a second one. The enzyme introduces an enzyme-bridged DNA double-strand break in one double helix through which a second duplex can be passed. Topoisomerase IIbeta potentiates the inhibitory effects of mitoxantrone and mAMSA on cell growth Homo sapiens