Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-di(furan-2-yl)-5H-chromeno[4,3-b]pyridine | 11.6% inhibition at 0.1 mM | Homo sapiens | |
2,4-di(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 10.6% inhibition at 0.1 mM | Homo sapiens | |
2,4-di(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 7.9% inhibition at 0.1 mM | Homo sapiens | |
2,4-di(thiophen-3-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2,4-diphenyl-5H-chromeno[4,3-b]pyridine | 15.4% inhibition at 0.1 mM | Homo sapiens | |
2-(furan-2-yl)-4-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 2.0% inhibition at 0.1 mM | Homo sapiens | |
2-(furan-2-yl)-4-(pyridin-3-yl)-5H-chromeno[4,3-b]pyridine | 5.6% inhibition at 0.1 mM | Homo sapiens | |
2-(furan-2-yl)-4-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 6.8% inhibition at 0.1 mM | Homo sapiens | |
2-(furan-2-yl)-4-phenyl-5H-chromeno[4,3-b]pyridine | 28.4% inhibition at 0.1 mM | Homo sapiens | |
2-(pyridin-2-yl)-4-(pyridin-3-yl)-5H-chromeno[4,3-b]pyridine | 8.6% inhibition at 0.1 mM | Homo sapiens | |
2-(pyridin-2-yl)-4-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 19.4% inhibition at 0.1 mM | Homo sapiens | |
2-phenyl-4-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 8.6% inhibition at 0.1 mM | Homo sapiens | |
2-phenyl-4-(pyridin-3-yl)-5H-chromeno[4,3-b]pyridine | 14.0% inhibition at 0.1 mM | Homo sapiens | |
2-phenyl-4-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 10.8% inhibition at 0.1 mM | Homo sapiens | |
2-phenyl-4-(thiophen-3-yl)-5H-chromeno[4,3-b]pyridine | 17.6% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-2-yl)-2-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 23.4% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-2-yl)-2-(thiophen-2-yl)-5H-chromeno [4,3-b]pyridine | 14.1% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-2-yl)-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
4-(furan-2-yl)-2-phenyl-5H-chromeno[4,3-b]pyridine | 11.5% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-3-yl)-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 8.4% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-3-yl)-2-phenyl-5H-chromeno[4,3-b]pyridine | 10.5% inhibition at 0.1 mM | Homo sapiens | |
4-(pyridin-2-yl)-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 8.5% inhibition at 0.1 mM | Homo sapiens | |
4-(pyridin-2-yl)-2-(thiophen-3-yl)-5H-chromeno[4,3-b]pyridine | 25.3% inhibition at 0.1 mM | Homo sapiens | |
4-phenyl-2-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 7.2% inhibition at 0.1 mM | Homo sapiens | |
4-phenyl-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 7.5% inhibition at 0.1 mM | Homo sapiens | |
camptothecin | - |
Homo sapiens | |
etoposide | - |
Homo sapiens | |
additional information | synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase II inhibitory activity, cytotoxicity, and structure-activity relationship, overview. 2-Furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | DNA topo IIalpha | Homo sapiens | - |
DU-145 cell | a prostate tumor cell line | Homo sapiens | - |
HCT-15 cell | a colorectal adenocarcinoma cell line | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HL-60 cell | a myeloid leukemic tumor cell line | Homo sapiens | - |
MDA-MB-231 cell | a breast tumor cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate for DNA topo IIalpha is supercoiled pBR322 plasmid DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA topo IIalpha | - |
Homo sapiens |
Topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |