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Literature summary for 5.6.2.2 extracted from

  • Nevin, L.M.; Xiao, T.; Staub, W.; Baier, H.
    Topoisomerase IIbeta is required for lamina-specific targeting of retinal ganglion cell axons and dendrites (2011), Development, 138, 2457-2465.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Protein Variants

Protein Variants Comment Organism
additional information construction of a mutant top2b lacking the domains necessary to bind and cleave the g-strand, as well as the exit gate for the t-strand, phenotype, overview Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Danio rerio 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Danio rerio TL / WIK
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Danio rerio
-
ganglion axons and dendrites Danio rerio
-
larva
-
 Danio rerio
-
additional information during fish developement, top2b mRNA is broadly expressed at early stages and becomes restricted to the central nervous system later. Noto heterozygotes in the TL strain are crossed with fish from the highly polymorphic WIK strain, and adult TL/WIK noto heterozygotes are bred repeatedly to generate TL/WIK recombinant wild-type and mutant larvae Danio rerio
-
neuron
-
 Danio rerio
-
retina
-
 Danio rerio
-

Synonyms

Synonyms Comment Organism
Top2b
-
 Danio rerio
topoisomerase IIbeta
-
 Danio rerio

Cofactor

Cofactor Comment Organism Structure
ATP Top2b contains an N-terminal ATPase region, which initially binds the t-strand, and part of the adjacent domain that transduces the power of ATP hydrolysis into a conformational change Danio rerio

General Information

General Information Comment Organism
malfunction GC axon and tectal neurite targeting are aberrant in the noto mutant tectum. The noto mutant also has neurite organization defects in the tectal neuropil, phenotype, overview. In chimeras in which wild-type axons innervate a mutant tectum, laminar targeting is free of errors. By contrast, mutant axons innervating the SFGS lamina of wild-type tectum appear disorganized and trespass between sublaminae Danio rerio
physiological function Top2b is a DNA-modifying enzyme that binds two double helices, cleaves one, the g-strand, and passes the other, the t-strand, through the break, and then re-anneals the cleaved strand. Topoisomerase IIbeta is required showing a specific, retina-autonomous role in GC axon lamina-specific targeting of retinal ganglion cell axons and dendrites, overview Danio rerio