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Literature summary for 5.6.2.2 extracted from

  • Na, Y.; Nam, J.M.
    Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy- and thiiranylmethoxy-chalcone derivatives (2011), Bioorg. Med. Chem. Lett., 21, 211-214.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
(2E)-1,3-bis[4-(oxiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-1,3-bis[4-(thiiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-1-(4-methoxyphenyl)-3-[4-(oxiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-1-(4-methoxyphenyl)-3-[4-(thiiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-1-[2,4-bis(thiiran-2-ylmethoxy)phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-3-(4-methoxyphenyl)-1-[4-(oxiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-3-(4-methoxyphenyl)-1-[4-(thiiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-3-[2-methoxy-4-(oxiran-2-ylmethoxy)phenyl]-1-[4-(oxiran-2-ylmethoxy)phenyl]prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
(2E)-3-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
1,3-bis(oxiran-2-ylmethoxy)-9H-xanthen-9-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
6-hydroxy-8-(thiiran-2-ylmethoxy)-5H-chromeno[2,3-b]pyridin-5-one inhibition in vivo in cancer cells, IC50 values, overview Homo sapiens
adriamycin
-
 Homo sapiens
camptothecin
-
 Homo sapiens
etoposide
-
 Homo sapiens
licochalcone A
-
 Homo sapiens
licochalcone E
-
 Homo sapiens
additional information synthesis and inhibitory potencial of bisoxiranylmethoxy- and bisthiiranylmethoxy-chalcone derivatives on topoisomerase II, overview. No inhibition of topoisomerase I, EC 5.99.1.2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
HCT-15 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Homo sapiens