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Literature summary for 5.6.2.2 extracted from

  • Sciandrello, G.; Mauro, M.; Caradonna, F.; Catanzaro, I.; Saverini, M.; Barbata, G.
    Acrylamide catalytically inhibits topoisomerase II in V79 cells (2010), Toxicol. In Vitro, 24, 830-834.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
Acrylamide acrylamide is a catalytic inhibitor, no enzyme poison, it antagonizes the effect of etoposide, a topoisomerase II poison, and inhibits the enzyme in vivo in V-79 cells. Acrylamide reduces the level of catalytically active cellular topoisomerase II available for the action of etoposide. Assay in presence of DTT Cricetulus griseus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Cricetulus griseus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
V-79 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme converts kinetoplast DNA to the decatenated form. Cleavage of pBR322 DNA Cricetulus griseus ?
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Cricetulus griseus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cricetulus griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Cricetulus griseus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cricetulus griseus