Literature summary for 5.6.2.2 extracted from

Shuai, L.; Wang, S.; Zhang, L.; Fu, B.; Zhou, X.
Cationic porphyrins and analogues as new DNA topoisomerase I and II inhibitors (2009), Chem. Biodivers., 6, 827-837.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1,1',1''-[(6,9-dihydroporphyrin-5,10,15-triyl-k2N22,N24)tris(benzene-4,1-diyloxyethane-2,1-diyl)]tris[1-methylpiperidiniumato(2-)])copper(3+)	strong inhibition	Homo sapiens
(3,3',3''-[(6,9-dihydroporphyrin-5,10,15-triyl-k2N22,N24)tris(benzene-4,1-diyloxy)]tris(N,N,N-trimethylpropan-1-aminiumato)(2-))copper(3+)	strong inhibition	Homo sapiens
{1,1',1'',1'''-[(1,4-dihydroporphyrin-5,10,15,20-tetrayl-k4N21,N22,N23,N24)tetrakis(benzene-4,1-diylmethanediyl)]tetrakis[1-methylpiperidiniumato(2-)]}nickel(4+) tetraiodide	strong inhibition	Homo sapiens
{2,2',2'',2''',2'''',2''''',2'''''',2'''''''-[(5,28-dihydro-29H,31H-tetrabenzoporphine-2,3,9,10,16,17,23,24-octayl-k4N29,N30,N31,N32)octasulfanediyl]octakis(N,N-diethyl-N-methylethanaminiumato)(2-)}zinc(8+) octaiodide	strong inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
topo II	-	Homo sapiens
Topoisomerase II	-	Homo sapiens

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Release 2023.1 (January 2023)