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Literature summary for 5.6.2.2 extracted from
- Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons (2009), Biochemistry, 48, 1439-1441.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | presence of a nick at one scissile bond dramatically increases the rate of cleavage by human topoisomerase IIalpha at the scissile bond on the opposite strand | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | topoisomerase II modulates DNA topology by generating double-stranded breaks in DNA. The presence of a nick at one scissile bond dramatically increases the rate of cleavage by human topoisomerase IIalpha at the scissile bond on the opposite strand, mechanism, overview | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topoisomerase II | - |
Homo sapiens |
| topoisomerase IIalpha | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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