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Literature summary for 5.6.2.2 extracted from
- Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning (2008), Toxicol. Appl. Pharmacol., 227, 331-338.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-[(10Z,13E,15E)-heptadeca-10,13,15-trien-1-yl]benzene-1,4-diol | irreversible inhibition of Topo IIalpha activity through the accumulation of Topo II-DNA cleavable complexes | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HL-60 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| topo II | - |
Homo sapiens |
| Topoisomerase II | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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