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Literature summary for 5.6.2.2 extracted from
- DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpoint (2008), Mol. Biol. Cell, 19, 4421-4433.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Top2 promotes tension checkpoint arrest and chromatid detachment in Mtw1 mutants with affected kinetochore protein Mtw1 | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | Top2 plays a role in centromeric chromatin compaction | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Top2 plays a role in centromeric chromatin compaction | Saccharomyces cerevisiae | ? | - |
? | |
| supercoiled DNA + ATP + H2O | - |
Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase II | - |
Saccharomyces cerevisiae |
| Top2 | - |
Saccharomyces cerevisiae |
| topo II | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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