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Literature summary for 5.6.2.2 extracted from
- Vaccinia virus DNA ligase recruits cellular topoisomerase II to sites of viral replication and assembly (2008), J. Virol., 82, 5922-5932.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| etoposide | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | during infection with Vaccinia virus, topoisomerase IIalpha and IIbeta antigens are recruited to cytoplasmic sites of virus replication | Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 174000 | - |
Topo IIalpha, SDS-PAGE | Homo sapiens |
| 183000 | - |
Topo IIbeta, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topo IIalpha | isozyme | Homo sapiens |
| Topo IIbeta | isozyme | Homo sapiens |
| topoisomerase IIalpha | isozyme | Homo sapiens |
| topoisomerase IIbeta | isozyme | Homo sapiens |
| type II topoisomerase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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