Literature summary for 5.6.2.2 extracted from

Di Leo, A.; Biganzoli, L.; Claudino, W.; Licitra, S.; Pestrin, M.; Larsimont, D.
Topoisomerase II alpha as a marker predicting anthracyclines activity in early breast cancer patients: ready for the primetime? (2008), Eur. J. Cancer, 44, 2791-2798.

Search for more literature for 5.6.2.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	topo II gene amplification is associated with increased tumour sensitivity to anthracyclines	Homo sapiens

Application

Application	Comment	Organism
medicine	topoisomerase II alpha is a marker predicting anthracyclines activity in early breast cancer patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA + ATP + H2O	-	Homo sapiens	catenated DNA networks + ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
topo II	-	Homo sapiens
topoisomerase II alpha	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)