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Literature summary for 5.6.2.2 extracted from

  • Dawlaty, M.M.; Malureanu, L.; Jeganathan, K.B.; Kao, E.; Sustmann, C.; Tahk, S.; Shuai, K.; Grosschedl, R.; van Deursen, J.M.
    Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha (2008), Cell, 133, 103-115.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Activating Compound

Activating Compound Comment Organism Structure
RanBP2 RanBP2 sumoylates Topo IIalpha, this modification is required for its proper localization to inner centromeres during mitosis, RanBP2 insufficient mice are prone to carcinogen-induced and spontaneous tumors Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
centromere
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
sumoylation RanBP2 sumoylates Topo IIalpha in mitosis, this modification is required for its proper localization to inner centromeres Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Mus musculus catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Topo IIalpha isoform Mus musculus
topoisomerase IIalpha
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus