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Literature summary for 5.6.2.2 extracted from

  • Barret, J.M.; Kruczynski, A.; Vispe, S.; Annereau, J.P.; Brel, V.; Guminski, Y.; Delcros, J.G.; Lansiaux, A.; Guilbaud, N.; Imbert, T.; Bailly, C.
    F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system (2008), Cancer Res., 68, 9845-9853.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
etoposide
-
 Cricetulus griseus
F14512 potent inhibitor, decreased sensitivity of L-1210 cells to F14512 in the presence of putrescine, spermidine, and spermine Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-
CHO-K1 cell
-
 Cricetulus griseus
-
CHO-MG cell
-
 Cricetulus griseus
-
CHO-XRS6 cell
-
 Cricetulus griseus
-
L-1210 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Cricetulus griseus catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Cricetulus griseus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cricetulus griseus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000026
-
 in CHO-XRS6 cells Cricetulus griseus F14512
0.0000109
-
 in CHO-K1 cells Cricetulus griseus F14512
0.00012
-
 in CHO cells Cricetulus griseus F14512
0.000194
-
 in CHO-K1 cells Cricetulus griseus etoposide
0.000418
-
 in CHO-XRS6 cells Cricetulus griseus etoposide
0.0087
-
 in CHO-MG cells Cricetulus griseus F14512