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Literature summary for 5.6.2.2 extracted from

  • Agostinho, M.; Santos, V.; Ferreira, F.; Costa, R.; Cardoso, J.; Pinheiro, I.; Rino, J.; Jaffray, E.; Hay, R.T.; Ferreira, J.
    Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity (2008), Cancer Res., 68, 2409-2418.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
PIASy small ubiquitin-like modifier ligase for topoisomerase 2 alpha Homo sapiens
small ubiquitin-like modifier 1 required for the mitotic function of the enzyme Homo sapiens
small ubiquitin-like modifier 2 required for the mitotic function of the enzyme Homo sapiens
small ubiquitin-like modifier 3 required for the mitotic function of the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
doxorubicin also called adriamycin Homo sapiens
etoposide
-
Homo sapiens
ICRF-187
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
chromosome
-
Homo sapiens 5694
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
sumoylation
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
Homo sapiens catenated DNA networks + ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
topoisomerase 2 alpha
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens