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Literature summary for 5.6.2.2 extracted from
- RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres (2008), Cancer Cell, 13, 293-295.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| RanBP2 | acts as a small ubiquitin-like modifier ligase für TopoII and is required for the stabilizing sumolyation of the enzyme | Mus musculus | |
| small ubiquitin-like modifier | - |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | TopoIIalpha is essential for chromosome segregation performing the DNA surgery necessary to decatenate replicated chromosomes | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | TopoIIalpha is essential for chromosome segregation performing the DNA surgery necessary to decatenate replicated chromosomes | Mus musculus | ? | - |
? | |
| supercoiled DNA + ATP + H2O | - |
Mus musculus | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| topoIIalpha | - |
Mus musculus |
| Topoisomerase II | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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