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Literature summary for 5.6.2.2 extracted from

  • Woo, S.; Kang, D.; Kim, J.; Lee, C.; Lee, E.; Jahng, Y.; Kwon, Y.; Na, Y.
    Synthesis, cytotoxicity and topoisomerase II inhibition study of new thioxanthone analogues (2008), Bull. Korean Chem. Soc., 29, 471-474.
No PubMed abstract available
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
1-hydroxy-3-(2',3'-epoxypropoxy)thioxanthone 21% inhibition at 0.1 mM Homo sapiens
1-hydroxy-3-(3'-chloro-2'-hydroxy-1'-propoxy)thioxanthone 84% inhibition at 0.1 mM Homo sapiens
1-hydroxy-3-(3'-chloro-2'-thioyl-1'-propoxy)thioxanthone 16% inhibition at 0.1 mM Homo sapiens
etoposide 70% inhibition at 0.1 mM Homo sapiens
additional information not inhibited by 1-hydroxy-3-(2',3'-thioepoxypropoxy)thioxanthone Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens