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Literature summary for 5.6.2.2 extracted from

  • Filosa, R.; Peduto, A.; Micco, S.D.; Caprariis, P.; Festa, M.; Petrella, A.; Capranico, G.; Bifulco, G.
    Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors (2009), Bioorg. Med. Chem., 17, 13-24.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
amonafide
-
 Homo sapiens
DMP 840 synonym bisnafide Homo sapiens
LU 79553 synonym elinafide Homo sapiens
mitonafide
-
 Homo sapiens
N,N'-bis[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benz[de]-isoquinolin-2-yl)]butylaminoethyl-2-propanediamine
-
 Homo sapiens
N,N'-bis[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benz[de]-isoquinolin-2-yl)]propane-2-ethanediamine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DNA topoisomerase II
-
 Homo sapiens
topo II
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens