Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.2 extracted from

  • Hassan, G.S.; Farag, N.A.; Hegazy, G.H.; Arafa, R.K.
    Design and synthesis of novel benzopyran-2-one derivatives of expected antimicrobial activity through DNA gyrase-B inhibition (2008), Arch. Pharm., 341, 725-733.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Bacillus subtilis
1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Candida albicans
1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Escherichia coli
1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Staphylococcus aureus
1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Bacillus subtilis
2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one
-
 Bacillus subtilis
2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one
-
 Escherichia coli
3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole
-
 Staphylococcus aureus
3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one
-
 Escherichia coli
3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one
-
 Staphylococcus aureus
3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one
-
 Bacillus subtilis
4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one
-
 Bacillus subtilis
4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one
-
 Staphylococcus aureus
Amphotericin B
-
 Candida albicans
additional information not inhibited by 3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one, 4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, and amphotericin B Bacillus subtilis
additional information not inhibited by 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide, 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one, 3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one, 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one, and tetracycline Candida albicans
additional information not inhibited by 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide, 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one, 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one 4a4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, and amphotericin B Escherichia coli
additional information not inhibited by 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide, 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one, and amphotericin B Staphylococcus aureus
tetracycline
-
 Bacillus subtilis
tetracycline
-
 Escherichia coli
tetracycline
-
 Staphylococcus aureus
y, Namen korrigieren: 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one
-
 Bacillus subtilis
y, Namen korrigieren: 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Candida albicans
-
-
-
Escherichia coli P0AES6
-
-
Micrococcus luteus
-
-
-
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Staphylococcus aureus catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O
-
 Bacillus subtilis catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O
-
 Micrococcus luteus catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O
-
 Candida albicans catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O
-
 Escherichia coli catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DNA gyrase-B
-
 Staphylococcus aureus
DNA gyrase-B
-
 Bacillus subtilis
DNA gyrase-B
-
 Micrococcus luteus
DNA gyrase-B
-
 Candida albicans
DNA gyrase-B
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Staphylococcus aureus
ATP
-
 Bacillus subtilis
ATP
-
 Micrococcus luteus
ATP
-
 Candida albicans
ATP
-
 Escherichia coli