Literature summary for 5.6.2.2 extracted from

Lyu, Y.L.; Lin, C.P.; Azarova, A.M.; Cai, L.; Wang, J.C.; Liu, L.F.
Role of topoisomerase IIbeta in the expression of developmentally regulated genes (2006), Mol. Cell. Biol., 26, 7929-7941.

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Protein Variants

Protein Variants	Comment	Organism
additional information	generation of transcription profiles of wild-type and enzyme knock-out mouse embryos. Only 1-4% of genes are affected in the mutant, but the expression of nearly 30% of developmentally regulated genes is either up- or down-regulated. The expression of genes encoding general cell growth functions and early differentiation markers is not affected	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	role of enzyme in activation/repression of developmentally regulated genes at late stages of neuronal differentiation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform topoisomerase IIbeta	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	together with histone deacetylase 2, preferential expression of enzyme in neurons which are in their later stages of differentiation	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	role of enzyme in activation/repression of developmentally regulated genes at late stages of neuronal differentiation	Mus musculus	?	-	?

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Release 2023.1 (January 2023)