Literature summary for 5.6.2.2 extracted from

Jo, J.Y.; Gonzalez de Mejia, E.; Lila, M.A.
Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols (2006), J. Agric. Food Chem., 54, 2083-2087.

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Inhibitors

Inhibitors	Comment	Organism	Structure
epicatechin gallate	-	Homo sapiens
myricetin	potentiating interaction between inhibitors myricetin and resveratrol	Homo sapiens
procyanidin B2	potentiating interactions between procyanidin B2 and epicatechin gallate, myricetin and resveratrol	Homo sapiens
resveratrol	potentiating interaction between inhibitors myricetin and resveratrol	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000029	-	pH 8.0, 37°C	Homo sapiens	epicatechin gallate
0.000039	-	pH 8.0, 37°C	Homo sapiens	myricetin
0.0045	-	pH 8.0, 37°C	Homo sapiens	procyanidin B2
0.0657	-	pH 8.0, 37°C	Homo sapiens	resveratrol

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Release 2023.1 (January 2023)