Protein Variants | Comment | Organism |
---|---|---|
C170A | potential site of quinone adduction. Mutant does not show reduced sensitivity to benzoquinone | Homo sapiens |
C392A | potential site of quinone adduction. Mutant shows 50% reduced sensitivity to benzoquinone and displays 2fold faster rates of DNA religation than wild-type. Mutation does not affect the ability of benzoquinone to block the N-terinal gate of the enzyme | Homo sapiens |
C405A | potential site of quinone adduction. Mutant shows 50% reduced sensitivity to benzoquinone and displays 2fold faster rates of DNA religation than wild-type. Mutation does not affect the ability of benzoquinone to block the N-terinal gate of the enzyme | Homo sapiens |
C455A | potential site of quinone adduction. Mutant does not show reduced sensitivity to benzoquinone | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzoquinone | inhibits DNA religation and blocks N-terminal gate of the protein by cross-linking its two protomer subunits. Adduction at C392 and C405 of protein is important for its action | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform IIalpha | - |