A772P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, about 10% activity compared to the recombinant wild-type enzyme in strain JN394t2-4 |
Homo sapiens |
F775P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, inactive mutant |
Homo sapiens |
H759A |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, the mutant shows reduced decatenation activity and amounts of etoposide-induced cleavable complexes compared to the wild-type enzyme |
Homo sapiens |
H759P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, the mutant shows about 50% reduced decatenation activity and amounts of etoposide-induced cleavable complexes compared to the wild-type enzyme |
Homo sapiens |
I769P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, nearly inactive mutant |
Homo sapiens |
L771P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, nearly inactive mutant |
Homo sapiens |
M762P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, mutant activity is similar to the wild-type activity |
Homo sapiens |
M765P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, nearly inactive mutant |
Homo sapiens |
M766P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, inactive mutant |
Homo sapiens |
N770P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, the mutant shows 30% reduced decatenation activity and amounts of etoposide-induced cleavable complexes compared to the wild-type enzyme |
Homo sapiens |
N774P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, mutant activity is similar to the wild-type activity |
Homo sapiens |
Q773P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, mutant activity is similar to the wild-type activity |
Homo sapiens |
T767P |
site-directed mutagenesis, mutation of a residue of the alpha-helix region responsible for anti-cancer drug sensitivity, mutant activity is similar to the wild-type activity |
Homo sapiens |