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Literature summary for 5.6.2.2 extracted from
- The cell cycle phases of DNA damage and repair initiated by topoisomerase II-targeting chemotherapeutic drugs (2005), Mutat. Res., 572, 27-44.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is a target for cancer chemotherapy | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dactinomycin | i.e. actinomycin D | Homo sapiens |  |
| daunomycin | i.e. daunorubicin | Homo sapiens | |
| doxorubin | i.e. adriamycin | Homo sapiens | |
| etoposide | - |
Homo sapiens | |
| mitoxanthrone | - |
Homo sapiens | |
| additional information | determination of enzyme inhibition in vitro and DNA damage and apoptosis rate in vivo in HeLa cells and A-549 cells by inhibitory drugs, overview | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TOPOII | - |
Homo sapiens |
| Topoisomerase II | - |
Homo sapiens |
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