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Literature summary for 5.6.2.2 extracted from
- Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions (2005), J. Agric. Food Chem., 53, 2489-2498.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibitory effect of grape, a Vitis sp. hybrid, cell culture extract fractions on enzyme activity, the fractions contain flavonoids and stilbenes which might be responsible for the inhibition, extract analysis reveals several compounds, overview | Homo sapiens | |
| quercetin | - |
Homo sapiens |  |
| resveratrol | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| KCl | - |
Homo sapiens | |
| Mg2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled pRYG DNA + ATP + H2O | relaxation and cleavage of supercoiled pRYG DNA | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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