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Literature summary for 5.6.2.2 extracted from
- Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity (2005), Chem. Res. Toxicol., 18, 1395-1404.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(4-hydroxy-3-methoxyphenyl)chromenylium-3,5,7-triol | anthocyanidin, inhibition of isozyme IIbeta decatenation activity | Homo sapiens |  |
| anthocyanidins | modulate the enzyme activity and affect cellular DNA integrity, high enzyme inhibition by anthocyanidins with vicinal hydroxyl groups like delphinidin or cyanidin, competitive to ethidium bromide in DNA intercalation | Homo sapiens | |
| cyanidin | anthocyanidin, complete inhibition of enzyme, isozyme IIalpha and IIbeta, decatenation activity at 0.01 mM, no stabilization of the DNA-enzyme intermediate in contrast to topoisomerase poisons | Homo sapiens | |
| delphinidin | anthocyanidin, complete inhibition of enzyme, isozyme IIalpha and IIbeta, decatenation activity at 0.01 mM, no stabilization of the DNA-enzyme intermediate in contrast to topoisomerase poisons | Homo sapiens | |
| malvidin | anthocyanidin, inhibition of isozyme IIbeta decatenation activity | Homo sapiens | |
| pelargonidin | anthocyanidin, inhibition of isozyme IIbeta decatenation activity | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
two isozymes IIalpha and IIbeta | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HT-29 cell | colon adenocarcinoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + ATP + H2O | decatenation of DNA | Homo sapiens | DNA + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.9 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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