Cloned (Comment) | Organism |
---|---|
overexpression of isozyme IIalpha in Saccharomyces cerevisiae | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-hydroquinone | inhibition mechanism | Homo sapiens | |
benzoquinone | alkylating agent, inhibits isozyme IIalpha via DNA cross-linking, forms cysteine sulfhydryl adducts, inhibits cell growth in vivo, which is 10fold increased in absence of cysteine, quantitative structure-activity analysis, structure of DNA binding, overview, inhibition mechanism | Homo sapiens | |
benzoquinone mustard compounds | induce the formation of DNA-protein complexes, quantitative structure-activity analysis, inhibition mechanism, overview | Homo sapiens | |
EO9 | inhibition mechanism | Homo sapiens | |
etoposide | - |
Homo sapiens | |
menadione | inhibition mechanism | Homo sapiens | |
additional information | IC50 values, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
KCl | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme IIalpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pBR322 DNA + ATP + H2O | decatenation, relaxation and cleavage of pBR322 DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | required for decatenation activity | Homo sapiens |