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Literature summary for 5.6.2.2 extracted from

  • Bal, C.; Baldeyrou, B.; Moz, F.; Lansiaux, A.; Colson, P.; Kraus-Berthier, L.; Leonce, S.; Pierre, A.; Boussard, M.F.; Rousseau, A.; Wierzbicki, M.; Bailly, C.
    Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II (2004), Biochem. Pharmacol., 68, 1911-1922.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
additional information cytotoxic effects of inhibitors on K562 and K562adr tumor cells, overview Homo sapiens
S35047 a phenyl derivative of 8-[2-(dialkylamino)ethoxy]-2,3-dimethoxy-5H-10H-indenol[1,2-b]indol-10-one-O-propynyl-oxime core structure, inhibition of topoisomerase II, intercalation with DNA causes cytoxic activity Homo sapiens
S35794 a derivative of 8-[2-(dialkylamino)ethoxy]-2,3-dimethoxy-5H-10H-indenol[1,2-b]indol-10-one-O-propynyl-oxime core structure, inhibition of topoisomerase II, intercalation with DNA causes cytoxic activity Homo sapiens
S36699 a derivative of 8-[2-(dialkylamino)ethoxy]-2,3-dimethoxy-5H-10H-indenol[1,2-b]indol-10-one-O-propynyl-oxime core structure, inhibition of topoisomerase II, intercalation with DNA causes cytoxic activity Homo sapiens
S36888 a derivative of 8-[2-(dialkylamino)ethoxy]-2,3-dimethoxy-5H-10H-indenol[1,2-b]indol-10-one-O-propynyl-oxime core structure, inhibition of topoisomerase II, intercalation with DNA causes cytoxic activity Homo sapiens
S36889 a derivative of 8-[2-(dialkylamino)ethoxy]-2,3-dimethoxy-5H-10H-indenol[1,2-b]indol-10-one-O-propynyl-oxime core structure, inhibition of topoisomerase II, intercalation with DNA causes cytoxic activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
K-562 cell chronic myeloid leukemia cell line Homo sapiens
-
K-562adr cell adriamycin-resistant K562 cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled pKMp27 DNA + ATP + H2O relaxation of supercoiled pKMp27 DNA Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 in vivo cytotoxic assay at Homo sapiens
7.8
-
 in vitro assay at Homo sapiens