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Literature summary for 5.6.2.2 extracted from

  • Bakshi, R.; Galande, S.; Muniyappa, K.
    Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIalpha (2001), J. Biomol. Struct. Dyn., 18, 749-760.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
poly(dG)
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus dual role for the topoisomerase IIalpha in vivo consistent with the notion that its sequestration to the chromatin might play a role in chromosome condensation and decondesation during spermatogenesis ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
topoiomerase IIalpha
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
form I DNA + ATP + H2O
-
Rattus norvegicus form IV DNA + ADP + phosphate
-
?
additional information dual role for the topoisomerase IIalpha in vivo consistent with the notion that its sequestration to the chromatin might play a role in chromosome condensation and decondesation during spermatogenesis Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
topo II
-
Rattus norvegicus