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Literature summary for 5.6.2.2 extracted from

  • Meng, L.H.; Zhang, J.S.; Ding, J.
    Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes (2001), Biochem. Pharmacol., 62, 733-741.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
salvicine 0.001 mM inhibits 40%, 0.005 mM inhibits 90%, IC50: 0.003 mM, inhibits by trapping enzyme-DNA cleavage complexes, which in turn produces anticancer effects Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kDNA + ATP + H2O decatenation Rattus norvegicus ?
-
?
supercoiled pBR322 DNA + ATP relaxation Rattus norvegicus ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
0.001 mM inhibits 40%, 0.005 mM inhibits 90%, IC50: 0.003 mM, inhibits by trapping enzyme-DNA cleavage complexes, which in turn produces anticancer effects Rattus norvegicus salvicine