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Literature summary for 5.6.2.2 extracted from
- Catalytic inhibition of DNA topoisomerase II by N-benzyladriamycin (AD 288) (2000), Biochem. Pharmacol., 60, 1621-1628.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-benzyladriamycin | inhibits by preventing the initial non-covalent binding of topoisomerase II to DNA | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| catenated kDNA + ATP + H2O | - |
Homo sapiens | unlinked monomer kDNA + ADP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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