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Literature summary for 5.6.2.2 extracted from
- Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy (1995), J. Biol. Chem., 270, 14998-15004.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ellipticines | mechanism of drug action, characterization of the interaction between ellipticine and the enzyme | Saccharomyces cerevisiae |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| network of DNA rings + ATP + H2O | decatenation | Saccharomyces cerevisiae | monomeric DNA circles + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? | |
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