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Literature summary for 5.6.2.2 extracted from
- Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C (1995), J. Biol. Chem., 270, 28357-28363.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | phosphorylation by protein kinase C strongly enhances activity | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| oligohistidine-tagged recombinant domains of topoisomerase IIalpha overexpressed in Escherichia coli | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| network of DNA rings + ATP + H2O | decatenation | Homo sapiens | monomeric DNA circles + ADP + phosphate | - |
? |  |
| supercoiled DNA + ATP + H2O | catenation | Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Homo sapiens | relaxed DNA + ADP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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