Literature summary for 5.6.2.2 extracted from

Inagaki, T.; Kaneda, K.; Suzuki, Y.; Hirai, H.; Nomura, E.; Sakakibara, T.; Yamauchi, Y.; Huang, L.H.; Norcia M.; Wondrack, L.M.; Sutcliffe, J.A.; Kojima, N.
CJ-12,372, a novel topoisomerase II inhibitor: Fermentation, isolation, structure elucidation and biological activities (1998), J. Antibiot., 51, 112-116.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Isochroman carboxylic acid	CJ-12,373, isolated from Penicillium sp. CL22557	Bacteria

Organism

Organism	UniProt	Comment	Textmining
Bacteria	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
network of DNA rings + ATP + H2O	decatenation	Bacteria	monomeric DNA circles + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	catenation	Bacteria	catenated DNA networks + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	relaxation	Bacteria	relaxed DNA + ADP + phosphate	-	?

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Release 2023.1 (January 2023)