Literature summary for 5.6.2.2 extracted from

Nabiev, I.; Chourpa, I.; Riou, J.F.; Nguyen, C.H.; Lavelle, F.; Manfait, M.
Molecular interactions of DNA-topoisomerase I and II inhibitor with DNA and topoisomerases and in ternary complexes: binding modes and biological effects for intoplicine derivatives (1994), Biochemistry, 33, 9013-9023.

Search for more literature for 5.6.2.2

Inhibitors

Inhibitors	Comment	Organism	Structure
intoplicine	molecular interactions of the inhibitor with DNA and topoisomerase II in ternary complexes. Binding modes and biological effects of Intoplicine derivatives	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
network of DNA rings + ATP + H2O	decatenation	Bos taurus	monomeric DNA circles + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	catenation	Bos taurus	catenated DNA networks + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	relaxation	Bos taurus	relaxed DNA + ADP + phosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)