Crystallization (Comment) | Organism |
---|---|
X-ray crystallographic analysis of the Dictyostelium discoideum myosin-2 motor domain complexes with magnesium(II)-ADP-metavanadate and the three pseudilin inhibitors pentabromopseudilin, pentachloropseudilin, and tribromodichloropseudilin, PDB IDs 2JJ9, 1VOM, and 2XO8 | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-(-)-blebbistatin | - |
Oryctolagus cuniculus | |
1-(4-methoxyphenyl)-2-phenyl-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(2-methoxyphenyl)-1-methyl-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)-1-methyl-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(3,5-dichloro-2-hydroxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(3,5-dichloro-2-methoxyphenyl)pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-tribromo-5-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-trichloro-5-(2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-trichloro-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-triiodo-5-(3,5-dichloro-2-methoxyphenyl)pyrrole | - |
Oryctolagus cuniculus | |
2,3,4-triiodo-5-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2,4-dichloro-6-(3,4,5-triiodo-1H-pyrrol-2-yl)phenol | - |
Oryctolagus cuniculus | |
2,4-difluoro-6-(3,4,5-triiodo-1H-pyrrol-2-yl)phenol | - |
Oryctolagus cuniculus | |
2-(2-hydroxyphenyl)-1-methyl-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(2-hydroxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(2-methoxyphenyl)-1-methyl-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-dibromo-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-dibromo-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-difluoro-2-methoxyphenyl)-1-(4-methylbenzene-1-sulfonyl)-2,5-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-difluoro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole | - |
Oryctolagus cuniculus | |
2-Methoxybenzaldehyde | - |
Oryctolagus cuniculus | |
3,5-dibromo-2-methoxybenzaldehyde | - |
Oryctolagus cuniculus | |
3,5-dichloro-2-methoxybenzaldehyde | - |
Oryctolagus cuniculus | |
3,5-difluoro-2-methoxybenzaldehyde | - |
Oryctolagus cuniculus | |
4-methoxy-N-[1-phenyl-4-(trimethylsilyl)but-3-yn-1-yl]aniline | - |
Oryctolagus cuniculus | |
additional information | pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a class of isoform-specific allosteric inhibitors of myosin ATPase. Application of the silver(I)-catalyzed cycloisomerization of N-(homopropargyl)toluene-sulfonamides to the total syntheses of the natural products and several non-natural analogues. Inhibitory effect of pentahalogenated pseudilins on myosin ATPase activity, overview | Oryctolagus cuniculus | |
N-(2-methoxybenzylidene)-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-(3,5-dibromo-2-methoxybenzylidene)-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-(3,5-difluoro-2-methoxybenzylidene)-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-benzyl-p-toluenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(2-methoxyphenyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dibromo-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dibromo-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dibromo-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dibromo-2-methoxyphenyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dichloro-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-dichloro-2-methoxyphenyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-difluoro-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-difluoro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-difluoro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(3,5-difluoro-2-methoxyphenyl)buta-2,3-dien-1-yl]-4-methylbenzene-1-sulfonamide | - |
Oryctolagus cuniculus | |
N-[1-(methoxyphenyl)-2-(trimethylsilyl)-buta-2,3-dienyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
pentabromopseudilin | - |
Oryctolagus cuniculus | |
pentachloropseudilin | - |
Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required, structure of myosin-2 complex with Mg2+-ADP-metavanadate | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + myosin bound to actin filament at position n | Oryctolagus cuniculus | - |
ADP + phosphate + myosin bound to actin filament at position n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + myosin bound to actin filament at position n | - |
Oryctolagus cuniculus | ADP + phosphate + myosin bound to actin filament at position n+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
myosin-2 ATPase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Oryctolagus cuniculus |