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Literature summary for 5.6.1.8 extracted from

  • Onishi, H.; Mikhailenko, S.V.; Morales, M.F.
    Toward understanding actin activation of myosin ATPase: the role of myosin surface loops (2006), Proc. Natl. Acad. Sci. USA, 103, 6136-6141.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
actin
-
Gallus gallus

Protein Variants

Protein Variants Comment Organism
D412A mutation in loop3, cardiomyopathy loop, involved in actin binding Gallus gallus
F547A mutation in loop 1, a hydrophobic triplet of residues, involved in actin binding Gallus gallus
I407A mutation in loop3, cardiomyopathy loop, involved in actin binding Gallus gallus
K652A mutation in loop 2, involved in actin binding Gallus gallus
K652A/K653A double mutation in loop 2, involved in actin binding Gallus gallus
K653A mutation in loop 2, involved in actin binding Gallus gallus
P548A mutation in loop 1, a hydrophobic triplet of residues, involved in actin binding Gallus gallus
V409A mutation in loop3, cardiomyopathy loop, involved in actin binding Gallus gallus
V413A mutation in loop3, cardiomyopathy loop, involved in actin binding Gallus gallus
V414A mutation in loop3, cardiomyopathy loop, involved in actin binding Gallus gallus
W546A mutation in loop 1, a hydrophobic triplet of residues, involved in actin binding Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + myosin bound to actin filament at position n Gallus gallus
-
ADP + phosphate + myosin bound to actin filament at position n+1
-
ir

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gizzard
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + myosin bound to actin filament at position n
-
Gallus gallus ADP + phosphate + myosin bound to actin filament at position n+1
-
ir

Synonyms

Synonyms Comment Organism
actomyosin
-
Gallus gallus
myosin ATPase
-
Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
ATPase assay Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
ATPase assay Gallus gallus