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Literature summary for 5.6.1.7 extracted from
- The structure and evolution of eukaryotic chaperonin-containing TCP-1 and its mechanism that folds actin into a protein spring (2018), Biochem. J., 475, 3009-3034 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H147R | the mutation is associated with hereditary sensory neuropathies | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| nucleolus | - |
Homo sapiens | 5730 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphate + unfolded actin | Mus musculus | - |
ATP + H2O + folded actin | - |
? |  |
| ADP + phosphate + unfolded actin | Homo sapiens | - |
ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded actin | Saccharomyces cerevisiae | - |
ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded actin | Bos taurus | - |
ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded tubulin | Mus musculus | - |
ATP + H2O + folded tubulin | - |
? | |
| ADP + phosphate + unfolded tubulin | Homo sapiens | - |
ATP + H2O + folded tubulin | - |
? | |
| ADP + phosphate + unfolded tubulin | Saccharomyces cerevisiae | - |
ATP + H2O + folded tubulin | - |
? | |
| ADP + phosphate + unfolded tubulin | Bos taurus | - |
ATP + H2O + folded tubulin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| additional information | signaling of CCT in many different cancer types, review: breast cancer cell, glioma cell, colorectal cancer cell, head and neck cancer cell, lymphoma cell, uterine cancer cell, small cell lung cancer cell, hepatocellular cancer cell | Homo sapiens | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphate + unfolded actin | - |
Mus musculus | ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded actin | - |
Homo sapiens | ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded actin | - |
Saccharomyces cerevisiae | ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded actin | - |
Bos taurus | ATP + H2O + folded actin | - |
? | |
| ADP + phosphate + unfolded tubulin | - |
Mus musculus | ATP + H2O + folded tubulin | - |
? | |
| ADP + phosphate + unfolded tubulin | - |
Homo sapiens | ATP + H2O + folded tubulin | - |
? | |
| ADP + phosphate + unfolded tubulin | - |
Saccharomyces cerevisiae | ATP + H2O + folded tubulin | - |
? | |
| ADP + phosphate + unfolded tubulin | - |
Bos taurus | ATP + H2O + folded tubulin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCT ATPase | - |
Mus musculus |
| CCT ATPase | - |
Homo sapiens |
| CCT ATPase | - |
Saccharomyces cerevisiae |
| CCT ATPase | - |
Bos taurus |
| CCT1 | subunit | Mus musculus |
| CCT1 | subunit | Homo sapiens |
| CCT1 | subunit | Saccharomyces cerevisiae |
| CCT1 | subunit | Bos taurus |
| CCT2 | subunit | Mus musculus |
| CCT2 | subunit | Homo sapiens |
| CCT2 | subunit | Saccharomyces cerevisiae |
| CCT2 | subunit | Bos taurus |
| CCT3 | subunit | Mus musculus |
| CCT3 | subunit | Homo sapiens |
| CCT3 | subunit | Saccharomyces cerevisiae |
| CCT3 | subunit | Bos taurus |
| CCT4 | subunit | Mus musculus |
| CCT4 | subunit | Homo sapiens |
| CCT4 | subunit | Saccharomyces cerevisiae |
| CCT4 | subunit | Bos taurus |
| CCT5 | subunit | Mus musculus |
| CCT5 | subunit | Homo sapiens |
| CCT5 | subunit | Saccharomyces cerevisiae |
| CCT5 | subunit | Bos taurus |
| CCT6 | subunit | Mus musculus |
| CCT6 | subunit | Homo sapiens |
| CCT6 | subunit | Saccharomyces cerevisiae |
| CCT6 | subunit | Bos taurus |
| CCT7 | subunit | Mus musculus |
| CCT7 | subunit | Homo sapiens |
| CCT7 | subunit | Saccharomyces cerevisiae |
| CCT7 | subunit | Bos taurus |
| CCT8 | subunit | Mus musculus |
| CCT8 | subunit | Homo sapiens |
| CCT8 | subunit | Saccharomyces cerevisiae |
| CCT8 | subunit | Bos taurus |
| chaperonin-containing TCP-1 | - |
Mus musculus |
| chaperonin-containing TCP-1 | - |
Homo sapiens |
| chaperonin-containing TCP-1 | - |
Saccharomyces cerevisiae |
| chaperonin-containing TCP-1 | - |
Bos taurus |
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